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The Shocking Link Between Testosterone, Weight Gain, and Heart Disease

‹ Health BlogMen's Health ›Nutrition ›

Testosterone is often linked to masculinity, but this vital hormone plays crucial roles in both men and women. Beyond its reputation for driving muscle growth and libido, testosterone impacts nearly every system in the body. This article explores its functions, the effects of imbalances, and evidence-based methods to optimise its levels.

What Is Testosterone?

Testosterone is a steroid hormone produced in the testes in men and the ovaries and adrenal glands in women. Men typically have levels 10-20 times higher than women, but the hormone is vital for both sexes (Nassar & Leslie, 2021).

It regulates key functions, including:

  • Muscle and bone health
  • Mood and energy levels
  • Metabolises carbohydrates, fats and proteins
  • Sex drive and fertility
  • Red blood cell production

Testosterone also plays a key role in carbohydrate, fat and protein metabolism and has a major influence on body fat composition and muscle mass in the male.
For women, testosterone also influences ovarian function, sexual arousal, and overall wellbeing (Burger, 2002).

 


Why Is Testosterone Important?

Of all the androgens involved in regulating and maintaining body composition, testosterone is arguably the most well-known and significant, as it is closely linked to various health conditions, including metabolic syndrome, type 2 diabetes, and cardiovascular disease. (Kang H Y, 2013)

Testosterone is essential for overall health in both sexes. Proper levels support:

  • Cognitive function: Testosterone influences memory and focus, with lower levels linked to cognitive decline in ageing men and women (Carson & Rosano, 2012).
  • Heart health: Balanced testosterone levels correlate with improved cardiovascular function, although extremes—too low or too high—can be harmful (Vigen et al., 2013).
  • Metabolic health: Testosterone regulates fat distribution and energy production, impacting obesity and diabetes risk (Kelly & Jones, 2013).

 

 


What Happens When Testosterone Levels Are Imbalanced?

Testosterone deficiency is linked to increased fat mass, particularly central adiposity, along with reduced insulin sensitivity, impaired glucose tolerance, elevated triglycerides, and cholesterol, as well as low HDL cholesterol. These features are commonly associated with metabolic syndrome (MetS) and type 2 diabetes, both of which contribute to cardiovascular risk. 

Clinical trials have shown that testosterone replacement therapy can improve insulin resistance and glycaemic control in these conditions. It also helps reduce overall body fat, particularly truncal adiposity, while lowering cholesterol and triglyceride levels.(Kelly & Jones, 2013).
 

Testosterone Imbalance In Men

  • Low testosterone (hypogonadism): Symptoms include fatigue, depression, reduced muscle mass, erectile dysfunction, low libido, infertility, and osteoporosis (Bhasin et al., 2018). Untreated, it can impair cardiovascular health and increase the risk of metabolic syndrome.
  • High testosterone: Rare but possible, especially due to supplementation or certain medical conditions. It may lead to aggression, high blood pressure, acne, low sperm count or infertility, and an increased risk of cardiovascular events (Basaria et al., 2010).

High testosterone in males, also known as hypergonadism, can be caused by a number of underlying health and medical conditions, including:

  • Benign and malignant tumors in the testicles
  • Infections
  • Kidney and liver problems
  • Autoimmune disorders
  • Genetic abnormalities
  • Injury
     

Testosterone Imbalance In Women

  • Low testosterone: Women with insufficient testosterone may experience reduced libido, fatigue, poor concentration, and muscle weakness. These symptoms are especially common during menopause (Davison et al., 2005).
  • High testosterone: Commonly associated with polycystic ovary syndrome (PCOS), symptoms include irregular periods, acne, excess hair growth, and increased risk of insulin resistance and type 2 diabetes (Azziz et al., 2004).

 


How to Increase Testosterone Naturally

Low testosterone is increasingly common due to stress, poor diet, and sedentary lifestyles. Here’s how to boost levels based on research:

Diet

  • Zinc-rich foods: Zinc is critical for testosterone production. Foods like oysters, lean meat, and seeds improve levels (Prasad, 2013).
  • Healthy fats: Dietary fat intake, particularly monounsaturated fats, is linked to increased testosterone levels (Volek et al., 2001). Sources include avocados, nuts, and olive oil.
  • Vitamin D: Supplementing vitamin D3 increases testosterone in deficient individuals (Pilz et al., 2011).
  • Magnesium: Magnesium enhances testosterone levels, particularly in physically active individuals (Cinar et al., 2011).
  • High-quality proteins: Protein sources like eggs, chicken, and fish are essential for muscle repair and hormone synthesis.

 

Exercise

  • Strength training: Lifting weights or performing resistance exercises boosts testosterone, especially when engaging large muscle groups (West et al., 2011).
  • High-intensity interval training (HIIT): Short bursts of intense exercise increase testosterone more than steady-state cardio (Hackney, 2006).
  • Reduce sedentary time: Prolonged sitting is associated with lower testosterone levels (Aldred et al., 2009).

 


How to Lower Testosterone Naturally

For women with conditions like PCOS, lowering testosterone can alleviate symptoms. Lifestyle changes supported by science include:

Diet

  • Low-glycaemic index foods: These stabilise blood sugar, reducing insulin spikes that drive excessive testosterone production (Barber et al., 2006).
  • Anti-inflammatory foods: Turmeric, ginger, and omega-3 fatty acids lower systemic inflammation, indirectly helping balance hormones (Calder, 2006).
  • Limit sugar and processed carbs: Excess sugar can worsen insulin resistance and exacerbate hormonal imbalances (Paoli et al., 2013).

 

Exercise

  • Cardiovascular workouts: Aerobic exercise improves insulin sensitivity and reduces androgen levels in women with PCOS (Harrison et al., 2011).
  • Yoga or pilates: Stress reduction through mindful exercise helps lower cortisol, which indirectly regulates testosterone (de Sousa et al., 2015).

 


When to Seek Help

Testing testosterone levels is crucial if you experience symptoms of imbalance. Hormonal irregularities can point to underlying health issues such as thyroid dysfunction, adrenal disorders, or chronic stress.

Vitall’s at-home hormone test kits offer a simple and accurate way to check your testosterone levels. With fast results and expert insights, you can take charge of your health from the comfort of home.

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Testosterone & Estrogen Test

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Conclusion

Testosterone may be a small molecule, but its influence is monumental. Balancing testosterone is vital for optimising physical, emotional, and cognitive health in both men and women. By making informed choices about diet, exercise, and stress management, you can ensure your levels remain just right.

Take control of your hormonal health—because balance is the foundation of vitality.

 

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Scientific review

Doctors, Scientists & Experts Delivering Private Blood Testing Online

Ben Starling MSc.

Co-founder & Lead Biochemist - Vitall|Profile

Ben has over 25 years of experience in clinical diagnostics. He holds a degree in Medical Biochemistry and a Master's degree in Toxicology and founded Vitall to address the growing need for preventive health testing and clearer interpretation of laboratory biomarkers.

Reviewed on 04/12/2024

Next review due 04/12/2025

Review focus: Blood biomarkers, laboratory testing methodology, and biochemical interpretation.

This content has been reviewed for biochemical accuracy and interpretation of laboratory biomarkers, but does not replace advice from a qualified healthcare professional.

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References & Citations For The Shocking Link Between Testosterone, Weight Gain, and Heart Disease

  • Aldred, S., Rohalu, M., Edwards, K., and Burns, V. (2009). The effects of sedentary behaviour on testosterone levels in men. Journal of Endocrinology, 203(1), pp.45-50.
  • Azziz, R., Woods, K.S., Reyna, R., Key, T.J., and Knochenhauer, E.S. (2004). The prevalence and features of the polycystic ovary syndrome in an unselected population. The Journal of Clinical Endocrinology & Metabolism, 89(6), pp.2745-2749.
  • Barber, T.M., McCarthy, M.I., Wass, J.A.H., and Franks, S. (2006). Obesity and polycystic ovary syndrome. Clinical Endocrinology, 65(2), pp.137-145.
  • Basaria, S., Travison, T.G., Alford, D., Knapp, P.E., and Eder, R. (2010). Effects of testosterone supplementation in men with cardiovascular disease. New England Journal of Medicine, 363(2), pp.109-122.
  • Bhasin, S., Brito, J.P., Cunningham, G.R., Hayes, F.J., and Hodis, H.N. (2018). Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology & Metabolism, 103(5), pp.1715-1744.
  • Burger, H.G. (2002). Androgen production in women. Fertility and Sterility, 77(4), pp.3-5.
  • Calder, P.C. (2006). n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. The American Journal of Clinical Nutrition, 83(6), pp.1505S-1519S.
  • Cinar, V., Polat, A., and Baltaci, A.K. (2011). Effect of magnesium supplementation on testosterone levels. Biological Trace Element Research, 140(3), pp.320-326.
  • Davison, S.L., Bell, R., Donath, S., Montalto, J.G., and Davis, S.R. (2005). Low-dose testosterone improves well-being, mood, and sexual function in premenopausal women. Journal of Clinical Endocrinology & Metabolism, 90(7), pp.3846-3852.
  • Hackney, A.C. (2006). Exercise and male reproductive hormone function. Medicine and Science in Sports and Exercise, 38(10), pp.1797-1804.
  • Nassar, G.N., and Leslie, S.W. (2021). Testosterone. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK526128/
  • Pilz, S., Frisch, S., Koertke, H., Kuhn, J., and Drechsler, C. (2011). Effect of vitamin D supplementation on testosterone levels. Hormone and Metabolic Research, 43(3), pp.223-225.
  • Kelly DM, Jones TH. Testosterone: a metabolic hormone in health and disease. J Endocrinol. 2013 Apr 29;217(3):R25-45. Available at: https://pubmed.ncbi.nlm.nih.gov/23378050/ 
  • Kang HY. Beyond the male sex hormone: deciphering the metabolic and vascular actions of testosterone. J Endocrinol. 2013 Apr 29;217(3):C1-3. Available at: https://pubmed.ncbi.nlm.nih.gov/23528478/

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